Southern Illinois Vacation Packages

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Photo by Southernmost Illinois Tourism Bureau

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Your Southern Illinois Vacation

When adventure is calling, answer it with a vacation package to Southern Illinois. Well known for its culture and history, this is one destination you'll never forget. Start your trip to Southern Illinois with a few nights in O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Effingham is another city that draws travellers from far and wide. Lake Sara and Effingham Performance Centre are two of the leading places to see in this destination. Quit dreaming and get packing, because your Southern Illinois vacation is just clicks away with Expedia.

Top Southern Illinois Vacation Deals

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was CA $1,509, price is now CA $1,010 per person
CA $1,010
per person
Jun 12 - Jun 15
found 5 hours ago
Roundtrip non-stop flight included
Calgary (YYC) to St. Louis (STL)
9.2/10 Wonderful! (1,620 reviews)
Awesome place to stay with kids. Nice pool and hot tub.

Reviewed on Mar 24, 2026

Spacious 3-Bedroom with King Bed

Spacious 3-Bedroom with King Bed

4 out of 5
Central West End
Price was CA $1,961, price is now CA $1,606 per person
CA $1,606
per person
Jun 12 - Jun 15
found 5 hours ago
Roundtrip non-stop flight included
Calgary (YYC) to St. Louis (STL)
8.8/10 Excellent! (11 reviews)
Clean room nice area

Reviewed on Feb 1, 2026

The Cheshire

The Cheshire

4 out of 5
Price was CA $1,251, price is now CA $1,059 per person
CA $1,059
per person
Jun 12 - Jun 15
found 5 hours ago
Roundtrip non-stop flight included
Calgary (YYC) to St. Louis (STL)
8.6/10 Excellent! (1,009 reviews)
Very friendly staff. Reasonable price drinks

Reviewed on Mar 22, 2026

The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
Central West End
Price was CA $1,283, price is now CA $1,093 per person
CA $1,093
per person
Jun 12 - Jun 15
found 5 hours ago
Roundtrip non-stop flight included
Calgary (YYC) to St. Louis (STL)
9/10 Wonderful! (1,005 reviews)
The property was well maintained, and everybody was very helpful polite the day was phenomenal. We couldn’t ask for anything else. It was great.

Reviewed on Mar 17, 2026

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
Price was CA $1,370, price is now CA $1,171 per person
CA $1,171
per person
Jun 12 - Jun 15
found 5 hours ago
Roundtrip non-stop flight included
Calgary (YYC) to St. Louis (STL)
8.4/10 Very Good! (2,217 reviews)
Great hotel for the hockey tournament... very nice staff... great location. The air quality was poor nearing the casino and awful inside... otherwise a great stay

Reviewed on Mar 21, 2026

Where to stay in Southern Illinois

Find the best Southern Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southern Illinois
Aerial view of the iconic Gateway Arch and Mississippi River with urban skyline and bridges, Downtown St. Louis, Missouri, United States.

Eastport

If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.

Find hotels in Eastport

Ready to book your vacation to Southern Illinois?

 

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Southern Illinois Hotel Deals

Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
Fully refundableReserve now, pay when you stay
The price is CA $129 per night from Apr 14 to Apr 15
CA $129
CA $146 total
Apr 14 - Apr 15
includes taxes & fees
9.2/10 Wonderful! (1,013 reviews)
Clean room. Tasty breakfast and a nice surprise having a snack/dinner buffet. Staff was friendly and helpful.

Reviewed on Mar 25, 2026

Drury Inn & Suites St. Louis Fairview Heights
Best Western Delta Inn

Best Western Delta Inn

2.5 out of 5
1509 Hampton Dr Effingham IL
Fully refundableReserve now, pay when you stay
The price is CA $136 per night from Apr 3 to Apr 4
CA $136
CA $152 total
Apr 3 - Apr 4
includes taxes & fees
9.2/10 Wonderful! (1,001 reviews)
The furnishings in the room were quite worn and dated, as was the shower. The bed was comfortable, but the sofa was hard to sit on and felt very worn. The paint on the walls was partially rubbed off. Carpet was old.

Reviewed on Mar 24, 2026

Best Western Delta Inn
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive O'Fallon IL
Fully refundableReserve now, pay when you stay
The price is CA $146 per night from Apr 12 to Apr 13
CA $146
CA $169 total
Apr 12 - Apr 13
includes taxes & fees
9.6/10 Exceptional! (1,001 reviews)
The hotel is nice enough. But the staff is not very friendly or accommodating. They made my stay very stressful.

Reviewed on Mar 23, 2026

Drury Inn & Suites St. Louis O'Fallon, IL
See all 1,173 properties in Southern Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Discover the most popular places to visit in Southern Illinois

Superman Statue which includes a statue or sculpture as well as a small group of people

Superman Statue

Superman fans will love getting a photograph taken in front of this giant statue of the Man of Steel himself, dressed in his iconic red-and-blue guise.

Superman Statue

McKendree University

Enjoy the collegiate vibe at McKendree University during your stay in Lebanon. Attend a sporting event in this family-friendly area.

McKendree University

DuQuoin State Fairgrounds

Catch an event at DuQuoin State Fairgrounds during your trip to Du Quoin. Experience the area's festivals and live music.

DuQuoin State Fairgrounds

Frequently asked questions

Can I cancel my flight booking to Southern Illinois due to COVID-19?
If you haven't booked yet, check the terms and conditions of your preferred carrier. If you've already locked in your flight to Southern Illinois, click through to our Customer Service Portal. The information here will help determine which COVID-19 policies apply to your booking and advise the next steps.
What's the best way to find cheap flights to Southern Illinois that have flexible change policies?
At Expedia, we've been channeling our inner gymnast to bring you the most flexible fares around. Just click on "No change fee" under the filter heading "Flexible change policies" to find your perfect flight to Southern Illinois.
What are some of the general tips for travelers to Southern Illinois during the COVID-19 outbreak?
With new COVID-19 rules and measures to adhere to, travel looks a bit different at present. Here are some useful things to know before you hop on that plane to Southern Illinois:
  • Research the rules and restrictions in both your origin and destination. You may not be able to travel depending on local circumstances, so make sure you check before you lock in your flight.
  • Wear a face mask during airport screening. A TSA employee will ask you to temporarily lower your mask for ID purposes.
  • To minimize the risk of cross-contamination, place your boarding pass on the scanner yourself and then hold it up for inspection. Do not hand your pass directly to a TSA officer.
  • One liquid hand sanitizer container is now allowed in your carry-on baggage. It must be no larger than 12 oz (350 ml), and you'll need to take it out of your bag for X-ray scanning.
  • To reduce handling during the screening process, place items such as your phone, keys and wallet into your carry-on rather than the bins.
  • Transport your food items in a clear plastic bag and also put them in a screening bin. Keeping your food separate from your carry-on makes it less likely that a TSA agent will need to open your bag for inspection.

Which airlines fly to Southern Illinois?
Cape Air is a well-known carrier servicing Southern Illinois. Search for a ticket to Williamson County Regional Airport (MWA) and you'll have 160 Cape Air flights a month to pick from.
How can I find cheap tickets to Southern Illinois?
A useful strategy for scoring cheap tickets is to be flexible with your travel dates. Begin with searching for your flight to Southern Illinois, then click on the "flexible dates" box to compare prices for nearby days. Want another tip? Book in advance. To give you an idea of costs, was the lowest price for a flight to Southern Illinois in the last seven days.
How much is a flight to Southern Illinois?
In the last seven days, round-trip tickets to Southern Illinois sold for as low as and reached a maximum of . For one-way trips taking off from (), the lowest amount paid during this same period was .
What are the most popular airports to fly into in Southern Illinois?
The main gateway to Southern Illinois, about 160 flights cruise into Williamson County Regional Airport (MWA) each month. Keep an eye out for a rewarding deal, lock in your seat and get set to discover this sensational region.
When is the cheapest time to fly to Southern Illinois?
If you'd rather spend your vacation savings enjoying Southern Illinois rather than on your trip there, jet off earlier in the week. The most economical day to travel is usually Tuesday, with Monday close behind. With many folks keeping their travel to weekends, Saturday tends to have the most expensive airfares.
How much is a plane ticket to Southern Illinois?
In the last seven days, plane tickets varied between and . Check out our sensational deals to Southern Illinois, make a booking and then get ready for your getaway!
Which airlines with flights to Southern Illinois employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, airlines have implemented additional actions and measures to help their passengers get back in the air. Here are some great examples:
  • Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.