Southern Illinois Vacation Packages

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Your Southern Illinois Vacation

When adventure is calling, answer it with a vacation package to Southern Illinois. Well known for its culture and history, this is one destination you'll never forget. Start your trip to Southern Illinois with a few nights in O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Effingham is another city that draws travellers from far and wide. Lake Sara and Effingham Performance Centre are two of the leading places to see in this destination. Quit dreaming and get packing, because your Southern Illinois vacation is just clicks away with Expedia.

Top Southern Illinois Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Home2 Suites by Hilton St. Louis Downtown

Home2 Suites by Hilton St. Louis Downtown

3 out of 5
Downtown West
Price was CA $1,021, price is now CA $853 per person
CA $853
per person
Oct 21 - Oct 24
found 10 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to St. Louis (STL)
8/10 Very Good! (502 reviews)
Loved the historical property and surrounding historical activities.

Reviewed on Aug. 23, 2025

The Cheshire

The Cheshire

4 out of 5
Price was CA $1,110, price is now CA $919 per person
CA $919
per person
Oct 21 - Oct 24
found 10 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to St. Louis (STL)
8.6/10 Excellent! (1,001 reviews)
Old property but has some real charm. The breakfast is outstanding and good location near park.

Reviewed on Sep. 3, 2025

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Price was CA $1,092, price is now CA $918 per person
CA $918
per person
Oct 21 - Oct 24
found 10 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to St. Louis (STL)
8.8/10 Excellent! (1,017 reviews)
The property was excellent with all the art in the building. Be staff was excellent and very friendly, caring and accommodating.

Reviewed on Aug. 25, 2025

DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park

4 out of 5
Central West End
Price was CA $1,047, price is now CA $885 per person
CA $885
per person
Oct 21 - Oct 24
found 10 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to St. Louis (STL)
8.2/10 Very Good! (1,000 reviews)
Parking is terrible and you shouldn’t have to pay $15 to park then charge for breakfast when your paying all that money to stay!!

Reviewed on Aug. 23, 2025

Marriott St. Louis Airport

Marriott St. Louis Airport

4 out of 5
Edmundson
Price was CA $1,224, price is now CA $1,035 per person
CA $1,035
per person
Oct 21 - Oct 24
found 10 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to St. Louis (STL)
7.8/10 Good! (1,001 reviews)
I will definitely come back

Reviewed on Sep. 1, 2025

Where to stay in Southern Illinois

Find the best Southern Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southern Illinois
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Eastport

If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.

Find hotels in Eastport

Ready to book your vacation to Southern Illinois?

 

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Southern Illinois Hotel Deals

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street , Mount Vernon, IL
Fully refundableReserve now, pay when you stay
The price is CA $131 per night from Oct 5 to Oct 6
CA $131
CA $148 total
Oct 5 - Oct 6
includes taxes & fees
Drury Plaza Hotel Mt. Vernon
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr, Fairview Heights, IL
Fully refundableReserve now, pay when you stay
The price is CA $129 per night from Sep 11 to Sep 12
CA $129
CA $146 total
Sep 11 - Sep 12
includes taxes & fees
Drury Inn & Suites St. Louis Fairview Heights
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr, O'Fallon, IL
Fully refundableReserve now, pay when you stay
The price is CA $70 per night from Sep 10 to Sep 11
CA $70
CA $81 total
Sep 10 - Sep 11
includes taxes & fees
Super 8 by Wyndham O'Fallon
See all 1,057 properties in Southern Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Discover the most popular places to visit in Southern Illinois

Superman Statue which includes a statue or sculpture as well as a small group of people

Superman Statue

Superman fans will love getting a photograph taken in front of this giant statue of the Man of Steel himself, dressed in his iconic red-and-blue guise.

Superman Statue

DuQuoin State Fairgrounds

Catch an event at DuQuoin State Fairgrounds during your trip to Du Quoin. Experience the area's festivals and live music.

DuQuoin State Fairgrounds

McKendree University

Enjoy the collegiate vibe at McKendree University during your stay in Lebanon. Attend a sporting event in this family-friendly area.

McKendree University

Frequently asked questions

Can I cancel my flight booking to Southern Illinois due to COVID-19?
If you haven't booked yet, check the terms and conditions of your preferred carrier. If you've already locked in your flight to Southern Illinois, click through to our Customer Service Portal. The information here will help determine which COVID-19 policies apply to your booking and advise the next steps.
What's the best way to find cheap flights to Southern Illinois that have flexible change policies?
At Expedia, we've been channeling our inner gymnast to bring you the most flexible fares around. Just click on "No change fee" under the filter heading "Flexible change policies" to find your perfect flight to Southern Illinois.
What are some of the general tips for travelers to Southern Illinois during the COVID-19 outbreak?
With new COVID-19 rules and measures to adhere to, travel looks a bit different at present. Here are some useful things to know before you hop on that plane to Southern Illinois:
  • Research the rules and restrictions in both your origin and destination. You may not be able to travel depending on local circumstances, so make sure you check before you lock in your flight.
  • Wear a face mask during airport screening. A TSA employee will ask you to temporarily lower your mask for ID purposes.
  • To minimize the risk of cross-contamination, place your boarding pass on the scanner yourself and then hold it up for inspection. Do not hand your pass directly to a TSA officer.
  • One liquid hand sanitizer container is now allowed in your carry-on baggage. It must be no larger than 12 oz (350 ml), and you'll need to take it out of your bag for X-ray scanning.
  • To reduce handling during the screening process, place items such as your phone, keys and wallet into your carry-on rather than the bins.
  • Transport your food items in a clear plastic bag and also put them in a screening bin. Keeping your food separate from your carry-on makes it less likely that a TSA agent will need to open your bag for inspection.

Which airlines fly to Southern Illinois?
Cape Air is a well-known carrier servicing Southern Illinois. Search for a ticket to Williamson County Regional Airport (MWA) and you'll have 160 Cape Air flights a month to pick from.
How can I find cheap tickets to Southern Illinois?
A useful strategy for scoring cheap tickets is to be flexible with your travel dates. Begin with searching for your flight to Southern Illinois, then click on the "flexible dates" box to compare prices for nearby days. Want another tip? Book in advance. To give you an idea of costs, was the lowest price for a flight to Southern Illinois in the last seven days.
How much is a flight to Southern Illinois?
In the last seven days, round-trip tickets to Southern Illinois sold for as low as and reached a maximum of . For one-way trips taking off from (), the lowest amount paid during this same period was .
What are the most popular airports to fly into in Southern Illinois?
The main gateway to Southern Illinois, about 160 flights cruise into Williamson County Regional Airport (MWA) each month. Keep an eye out for a rewarding deal, lock in your seat and get set to discover this sensational region.
When is the cheapest time to fly to Southern Illinois?
If you'd rather spend your vacation savings enjoying Southern Illinois rather than on your trip there, jet off earlier in the week. The most economical day to travel is usually Tuesday, with Monday close behind. With many folks keeping their travel to weekends, Saturday tends to have the most expensive airfares.
How much is a plane ticket to Southern Illinois?
In the last seven days, plane tickets varied between and . Check out our sensational deals to Southern Illinois, make a booking and then get ready for your getaway!
Which airlines with flights to Southern Illinois employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, airlines have implemented additional actions and measures to help their passengers get back in the air. Here are some great examples:
  • Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.